模拟寒潮对高血压疾病的影响实验研究

张夏琨; 周骥; 张书余; 马守存; 王宝鉴

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DOI:10.7519/j.issn.1000-0526.2014.06.012

气象:2014,40(6):754-758

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模拟寒潮对高血压疾病的影响实验研究

张夏琨¹, 周骥², 张书余³, 马守存⁴, 王宝鉴⁵

(1.南京信息工程大学大气科学学院，南京 210044;2.上海市浦东新区气象局，上海 200030;3.中国气象局兰州干旱气象研究所，甘肃省干旱气候变化与减灾重点实验室，兰州 730020;4.青海省气象服务中心，西宁 810001;5.兰州中心气象台，兰州 730020)

Experimental Research of the Impact of Simulated Cold Wave on Hypertension Disease

ZHANG Xiakun¹, ZHOU Ji², ZHANG Shuyu³, MA Shoucun⁴, WANG Baojian⁵

(1.College of Atmospheric Sciences, Nanjing University of Information Science and Technology, Nanjing 210044;2.Pudong New Area Weather Office, Shanghai Meteorological Bureau, Shanghai 200030;3.Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province, Lanzhou Institute of Arid Meteorology, CMA, Lanzhou 730020;4.Qinghai Meteorological Service Center, Xining 810001;5.Lanzhou Central Meteorological Observatory, Lanzhou 730020)

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投稿时间：2013-07-17 修订日期：2013-11-12

中文摘要: 本文通过动物实验初步探讨了寒潮天气发生过程中对高血压疾病的影响。在张书余等（2013）研究的基础上，应用TEM1880气象环境模拟箱模拟寒潮温压变化，将27只健康大鼠按每组3个随机分为9组，分别为空白对照组、最低温前3 h组、最低温前1 h组、最低温组、最低温后1 h组、最低温后3 h组、全过程结束组、全过程结束后5 h组和全过程结束后7 h组，放入模拟箱内，使其受寒潮天气影响，按照寒潮天气过程发生的不同时间先后分批取出实验大鼠，测量各组大鼠的收缩压、心率、体重，并通过腹主动脉采血测量血脂、去甲肾上腺素、血管紧张素Ⅱ及全血粘度等。实验结果分析表明，在寒潮天气发生过程中，冷锋通过后，受冷高压控制，气温迅速下降，当气温达到最低时，全血粘度、去甲肾上腺素和血管紧张素Ⅱ等上升到最大值，致使健康大鼠血压升高，并维持到寒潮天气影响结束以后还不能立刻恢复正常。

中文关键词: 高血压，寒潮天气，影响

Abstract:Based on Zhang Shuyu’s research (2013), the impact of cold wave on hypertension disease is preliminarily discussed through the animal experiments. The cold wave process is simulated in the environmental test chamber (TEM1880). At the same time, 27 healthy rats are randomly divided into the control group, 3 hours before Tmin (minimum temperature) group, 1 hour before Tmin group, Tmin group, 1 hour after Tmin group, 3 hours after Tmin group, cold wave process group, 5 hours after the cold wave process group, 7 hours after the cold wave process group, respectively. Each group has 3 rats. All the groups except the control group are exposed to the cold environment and taken out in accordance with the developing progress of cold wave respectively. The following indexes are measured: systolic blood pressure (SBP), heart rate (HR), weight, blood lipid, noradrenaline (NA), angiotensin Ⅱ (Ang Ⅱ), whole blood viscosity (WBV), etc. The experimental results show that the air temperature decreases rapidly under the control of the high pressure after cold front leaves in the cold wave process. WBV, NA and Ang Ⅱ can rise to the maximum value at the Tmin, making blood pressure increase in experimental rats in the whole time, and are hard to return to the original level even after the cold wave.

keywords: hypertension, cold wave, impact

文章编号： 中图分类号： 文献标志码：

基金项目:国家自然科学基金项目(40975069)和公益性行业(气象)科研专项(GYHY201106034)共同资助

作者	单位
张夏琨	南京信息工程大学大气科学学院，南京 210044
周骥	上海市浦东新区气象局，上海 200030
张书余	中国气象局兰州干旱气象研究所，甘肃省干旱气候变化与减灾重点实验室，兰州 730020
马守存	青海省气象服务中心，西宁 810001
王宝鉴	兰州中心气象台，兰州 730020

Author Name	Affiliation
ZHANG Xiakun	College of Atmospheric Sciences, Nanjing University of Information Science and Technology, Nanjing 210044
ZHOU Ji	Pudong New Area Weather Office, Shanghai Meteorological Bureau, Shanghai 200030
ZHANG Shuyu	Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province, Lanzhou Institute of Arid Meteorology, CMA, Lanzhou 730020
MA Shoucun	Qinghai Meteorological Service Center, Xining 810001
WANG Baojian	Lanzhou Central Meteorological Observatory, Lanzhou 730020

引用文本：
张夏琨,周骥,张书余,马守存,王宝鉴,2014.模拟寒潮对高血压疾病的影响实验研究[J].气象,40(6):754-758.
ZHANG Xiakun,ZHOU Ji,ZHANG Shuyu,MA Shoucun,WANG Baojian,2014.Experimental Research of the Impact of Simulated Cold Wave on Hypertension Disease[J].Meteor Mon,40(6):754-758.